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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are usually focused on the practical aspects of study design, including recruitment and consent, 프라그마틱 환수율 adherence, and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and included participants from various geographical areas. This kind of heterogeneity, which is vital for pragmatic trials to be reliable and to reduce bias in the results is also essential. Too much heterogeneity, however could cause issues with the trial design.

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Pragmatic trials aim to mimic real-life settings and 프라그마틱 슬롯 팁 정품 확인법 (ragingbookmarks.com blog entry) achieve maximum external validity. They are typically requested by practitioners and policymakers to help guide their decisions. They are also a good method of determining the causality between an intervention and its outcomes. However, they should not be used as a substitute for explanatory trials.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study which includes recruitment, design, delivery of the intervention and follow-up.

The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.