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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized as a focus on the practical aspects of study design, including recruitment and consent, adherence and the use of standard equipment.

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A pragmatic trial that uses various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for a pragmatic trial to be valid and reduce bias in results, is also necessary. However excessive heterogeneity could lead to problems with the design of the trial.

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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically requested by practitioners and policymakers to guide their decisions. They are also a good method of determining the causality between an intervention and its results. However, they shouldn't be used in lieu for explanation studies.

The pragmatism idea is controversial, and there are questions regarding whether pragmatic trials could replace tests for explanations or if they should be an alternative to them. Schwartz and 프라그마틱 정품확인 Lellouch1 suggested the distinction between explanation trials, which validate a physiological or clinical hypothesis, and pragmatic trials, which inform the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic study, including recruitment, design, delivery of the intervention and its follow-up.

The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary care settings.